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Publications

• ATPase
• Th17

ATPase

N.B. Blatt, J.J. Bednarski, R.E. Warner, F. Leonetti, K.M. Johnson, A. Boitano, R. Yung, B.C. Richardson, K.J. Johnson, J.A. Ellman, A.W. Opipari Jr., and G.D. Glick, “Benzodiazepine-induced superoxide signalsB cell apoptosis: mechanistic insight and potential therapeutic utility”, J. Clin. Invest., 2002, 110, 1123.

J.J. Bednarski, R.E. Warner, T. Rao, F. Leonetti, R. Yung, B.C. Richardson, K.J. Johnson, J.A. Ellman, A.W. Opipari Jr., and G.D. Glick, “Attenuation of autoimmune disease in fas-deficient mice by treatment with a cytotoxic benzodiazepine”, Arthritis & Rheumatism, 2003, 48, 757.

A. Boitano, C.D. Emal, F. Leonetti, N.B. Blatt, T.A. Dineen, J.A. Ellman, W.R. Roush, A.W. Opipari Jr., and G.D. Glick, “Structure-activity studies of a novel cytotoxic benzodiazepine”, Bioorg. Med. Chem. Lett., 2003, 13, 3327.

A. Boitano, J.A. Ellman, G.D. Glick, and A.W. Opipari Jr., “The proapoptotic benzodiazepine Bz-423 affects the growth and survival of malignant B cells”, Cancer Res., 2003, 63, 6870.

J.J. Bednarski, C.A. Lyssiotis, R. Roush, A.E. Boitano, G.D. Glick, and A.W. Opipari Jr., “A novel benzodiazepine increases the sensitivity of B cells to receptor stimulation with synergistic effects on calcium signaling and apoptosis”, J. Biol. Chem., 2004, 279, 29615.

J. Varani, N. Bhagavathula, K.C. Nerusu, H. Sherzer, K. Fay, A.E. Boitano, G.D. Glick, K. Johnson, S. Kang, and A.W. Opipari Jr., “A novel benzodiazepine selectively inhibits keratinocyte proliferation and reduces retinoid-induced epidermal hyperplasia in organ-cultured human skin”, J. Pharmacol. Exp. Ther., 2005, 313, 56.

K.M. Johnson, X. Chen, A. Boitano, L. Swenson, A.W. Opipari Jr., and G.D. Glick, “Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423”, Chem.& Biol., 2005, 12, 485.

C.P. Price, G.D. Glick, and A.J. Matzger, “Dissecting the behavior of a promiscuous solvate former”, Angew. Chem. Int. Ed., 2006, 45, 2062.

T.B. Sundberg, G.M. Ney, C. Subramanian, A.W. Opipari Jr., and G.D. Glick, “The immunomodulatory benzodiazepine Bz-423 inhibits B-cell proliferation by targeting c-Myc protein for rapid and specific degradation”, Cancer Res., 2006, 66, 1775.

T.M. Francis, T.B. Sundberg, J. Cleary, T. Groendyke, A.W. Opipari Jr., and G.D. Glick, “Identification of cytotoxic, T-cell-selective 1,4-benzodiazepine-2,5-diones”, Bioorg. Med. Chem. Lett., 2006, 16, 2423.

K.M. Johnson, J. Cleary, C.A. Fierke, A.W. Opipari Jr., and G.D. Glick, “Mechanistic basis for therapeutic targeting of the mitochondrial F1Fo-ATPase”, ACS Chem. Biol., 2006, 1, 304.

J. Cleary, K.M. Johnson, A.W. Opipari Jr., and G.D. Glick, “Inhibition of the mitochondrial F1F0-ATPase by ligands of the peripheral benzodiazepine receptor”, Bioorg. Med. Chem. Lett., 2007, 17, 1667.

N. Bhagavathula, K.C. Nerusu, A. Hanosh, M.N. Aslam, T.B. Sundberg, A.W. Opipari Jr., K. Johnson, S. Kang, G.D. Glick, and J. Varani, “7-Chloro-5-( 4-hydroxyphenyl )-1-methyl-3-( naphthalen-2-ylmethyl )-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one (Bz-423), a benzodiazepine, suppresses keratinocyte proliferation and has antipsoriatic activity in the human skin-severe, combined immunodeficient mouse transplant model”, J. Pharmacol. Exp. Ther., 2008, 324, 938.

N.B. Blatt, A. Boitano, C.A. Lyssiotis, A.W. Opipari Jr., and G.D. Glick, “Bz-423 signals superoxide-dependent apoptosis in fibroblasts via selective activation of c-Jun N-terminal kinase, bak, and bax”, submitted.

Th17

I.I. Ivanov; B.S. McKenzie; L. Zhou; C.E. Tadokoro; A. Lepelley; J.J. Lafaille; D.J. Cua; D.R. Littman. “The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells”. Cell. 2006; 126: 1121.
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N. Manel; D. Unutmaz; D.R. Littman. “The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat”. Nature immunology. 2008; 9: 641.
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L. Zhou; J.E. Lopes; M.M.W. Chong; I.I. Ivanov; R. Min; G.D. Victora; Y. Shen; J. Du; Y.P. Rubtsov; A.Y. Rudensky; S.F. Ziegler; D.R. Littman. “TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function”. Nature. 2008; 453: 236.
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