CORPORATE OVERVIEW

Lycera Corporation is a biopharmaceutical company pioneering an innovative approach to discovering and developing novel oral medicines to treat high unmet-need autoimmune diseases. The company is targeting two novel pathways to develop new classes of selective, oral immunomodulators for the treatment of patients with diseases such as rheumatoid arthritis, multiple sclerosis, psoriasis and inflammatory bowel disease. Lycera’s goal is to develop drug candidates with efficacy and safety profiles that change the treatment paradigm for patients with autoimmune diseases. Based on preclinical studies, the company’s emerging drug candidates have the potential for previously unseen oral efficacy and improved safety compared to the current standard-of-care antiproliferative and immunosuppressive agents.

Together, Lycera’s world-class leadership and scientific teams and proprietary technology platforms firmly establish the company as an emerging leader in the immunology/inflammation field. Its core discovery research capabilities will help Lycera create an industry-leading oral autoimmune pipeline. Lycera believes it has two of the most promising oral small-molecule programs for treating autoimmune diseases: the Bioenergetics program, focused on modulating energy producing and tranducing pathways to selectively target and silence pathologically activated cells, and a program targeting the Th17 pathway through the inhibition of ROR-gamma.

Serious autoimmune diseases are a major and growing public health problem. In the United States, there are approximately 7.5 million cases of psoriasis [1], 400 thousand cases of multiple sclerosis [2], 1.3 million cases of rheumatoid arthritis [3] and one million cases of inflammatory bowel disease [4]. Currently available biologic drugs have been associated with significant risks including opportunistic infections and death and are typically very costly. Despite these limitations, they generate more than $13 billion in annual sales. There is a clear need for oral drugs that demonstrate the efficacy of biologics, but with improved safety and administration profiles.

Founded in 2006, Lycera is headquartered in Cambridge, Mass. and has a state-of-the-art research center in Ann Arbor, Mich.

  1. National Psoriasis Foundation.
  2. National MS Society.
  3. National Arthritis Data Workgroup.
  4. Clinical Gastroenterology and Hepatology, Volume 5, Issue 12, pages 1383-1384, December 2007.